The iMidazopyridazine
Imidazo[1,2-b]pyridazine
CAS: 766-55-2
Molecular Formula: C6H5N3
The iMidazopyridazine - Names and Identifiers
| Name | Imidazo[1,2-b]pyridazine |
| Synonyms | IPZ 2-b]pyridazine 1,5-Diazaindolizine Imdazo1,2-Bpyridazine Imidazo1,2-pyridazine The iMidazopyridazine IMIDAZO[1,2-B]PYRIDAZINE Imidazo[1,2-b]pyridazine imidazo[2,1-f]pyridazine Imidazo-[1,2-b]pyridazin Imidazo(1,2-b)pyridazine IMidazole and [1, 2 - b] pyridazine Imidazo[1,2-b]pyridazine hemi-hydrate |
| CAS | 766-55-2 |
| EINECS | 1308068-626-2 |
| InChI | InChI=1/C6H5N3/c1-2-6-7-4-5-9(6)8-3-1/h1-5H |
The iMidazopyridazine - Physico-chemical Properties
| Molecular Formula | C6H5N3 |
| Molar Mass | 119.12 |
| Density | 1.29±0.1 g/cm3(Predicted) |
| Melting Point | 54℃ |
| Solubility | Soluble in dimethylformamide. |
| Appearance | White to yellow crystals |
| Color | White to Light yellow to Light orange |
| Maximum wavelength(λmax) | ['222nm(MeOH)(lit.)'] |
| pKa | 5.30±0.30(Predicted) |
| Storage Condition | Inert atmosphere,Room Temperature |
| Refractive Index | 1.689 |
| MDL | MFCD07782103 |
The iMidazopyridazine - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| HS Code | 29335990 |
The iMidazopyridazine - Reference Information
| Application | imidazo [1,2-b] pyridazine can be used as a pharmaceutical synthesis intermediate, it can be prepared from 3-pyridophenone and 2-chloroethylamine hydrochloride, and can be used to prepare 3-ethynyl imidazo [1,2-b] pyridazine. |
| Use | imidazo [1,2-b] pyridazine is an organic chemical and an intermediate for the preparation of cefazolin. |
| preparation | 936g of g3-drylenone, G of chloroform were placed in a 2L reaction flask, add 122g of 2-chloroethylamine hydrochloride and 222g of triethylamine, add 10g of anhydrous sodium sulfate, stir at 20-25 ° C. For 1 hour, raise the temperature to 60 ° C. Reflux for 4 hours, TLC(EA:PE = 1:3) detected that the reaction of 3-pyridophenone was complete, the temperature was lowered to 20-25 ℃, 200g of water was added and stirred for 1 hour, and the mixture was left to stand and layered, the chloroform layer was dried over 20g of anhydrous magnesium sulfate for 3 hours and suction filtered to obtain imidazo [1,2-b] pyridazine. |
Last Update：2024-04-09 20:45:29
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